Dr. Alexandre Mezentsev, Research Associate Scientist

Building future with IOGEN!

Mezentsev, Alexandre, PhD

Address:

AV Mezentsev, PhD
Dept of Functional Genomics
room 302
3 Gubkina Street
Moscow, 119991
Russia

Tel: +7 (499) 132-08-74
Fax: +7 (499) 132-89-62
email: [email protected]

Research interests:

- Molecular mechanism and pathogenesis of psoriasis;

- Biomarkers of cancer and autoimmune disorders;

- Skin equivalent based on human and rodent tissues;

- Genetics of basidiomycetes;

- Biodegradation of toxic waste;

About me:

Russian scientist with 15 years of Canadian and American experience

is interested in collaborative projects capable to shed light on pathogenesis of genetic disorders. At the time, I am leading scientist in Functional Genomics. Started as a biochemist in 1991, I am capable to perform a wide range of experiments such as purification, cloning-blotting-transformation and organolytic culture. Unfortunately, there is still something that I do not know. However, it is not a reason to pass by if you are offering a job. I stay open to new carrier opportunities and do mind to discuss another one.

I am appointed by IOGEN. This is one of the finest Academic institutions abroad, with decades of history and a continuous line of governmental awards. Our founder, Nicolay Vavilov was a famous Soviet geneticist who ended his life in Stalin’s GULAG. IOGEN is known in Russia for its own scientific school. Many fine scientists, such as Profs. Dubinin NP, Sozinov AA, Schestakov SV led our Institute and gained it a reputation across the world. Currently, we are under leadership of Prof. Yankovsky NK who is known in scientific community for his works in human genomics.

I will appreciate if you prefer to stay longer and take a closer look through the site. I have a good tradition of keeping online my current and former projects, lab protocols, presentations, papers and published manuscripts. Being a human person, I also enjoy some activities outside the lab and would suggest you to check my photo album and family tree, created by my brother Vasily, which is also available in English in my own translation. I also translate songs that like. If you want an example of my art work you can find it here.

Education:
University degree:	Moscow State University, MS Diploma with honor in Biology, Moscow, Russia - USSR, 1991
Advanced degree:	Russian Academy of Science, PhD in Biology, Moscow, 1996

Employment:

Department of Functional Genomics at Vavilov Institute of General Genetics in Russia, Russian Academy of Science, Leading scientist in functional genomics

Recent publications:

Articles are provided as PDF-files and you may need a pdf-viewer to open them. I personally use and recommend friends to use Foxit, one of the most accurate pdf-readers in the world.

(http://www.foxitsoftware.com/Secure_PDF_Reader/)

Printed papers, 5/20:

o    Wondimu A, Weir L, Robertson D, Mezentsev A, Kalachikov S, Panteleyev AA. Loss of Arnt (Hif1β) in mouse epidermis triggers dermal angiogenesis, blood vessel dilation and clotting defects. Lab Invest. 2011 Sep 26. doi: 10.1038/labinvest.2011.134.

o    Mezentsev A. Ming L. and Amundson S. Involvement of HNF4A in the low-dose radiation response of a human 3-dimensional tissue model (2010) BMC Genomics, submission # 1963470400401398.

o    Geng S., Mezentsev A., Kalachikov S., Raith K., Roop D. and Panteleyev A. Targeted ablation of Arnt in mouse epidermis results in profound defects in desquamation and epidermal barrier function (2006) J Cell Sci. 119(23), P4901-12.

o    Seta F, Patil K, Bellner L, Mezentsev A, Kemp R, Dunn MW, Schwartzman ML. Inhibition of VEGF expression and corneal neovascularization by siRNA targeting cytochrome P450 4B1. (2007) Prostaglandins Other Lipid Mediat. 84(3-4), 116-27.

o    Mezentsev A, Mastyugin V, Ashkar S, Seta F, Reddy S, Falck JR and Laniado-Schwartzman M. Transfection CYP4B1 into the cornea increases angiogenic activity of the limbal vessels (2005) J Pharmacol Exp Ther. 315(1), P42-50.

Attendance of domestic and international meetings:

Total: 36 oral presentations and posters

Mezentsev AV and Bruskin SA. Biomarkers and molecular mechanism of psoriasis. The 10^th Russian-American collaboration workshop on biomarkers of the diseases. (2012) Moscow.

Mezentsev A and Amundson SA. Response to low and high doses of proton irradiation in 3-dimensional tissue model Epi-200. The 54th Annual Meeting of The Society for Radiological Research. (2008) Boston.

Amundson SA, Brenner DJ and Mezentsev A. Mechanistic and quantitative studies of bystander responses in 3-D tissues for low-dose radiation risk estimation (2007) The 7th Low Dose Radiation Workshop, Washington DC.

Mezentsev A, Kalachikov SM. and Panteleyev AA. Regulation of Epidermal Late- Differentiation Genes via Arnt-dependent Pathway in Primary Mouse Keratinocytes Requires Chromatin Remodeling. Society for Investigative Dermatology Annual Meeting (2006) J. Invest. Derm. 126, S4, P.69.

Mezentsev A, Kalachikov SM. and Panteleyev AA. The Patterns of Periderm Shedding in Mice and the Role of Arnt in Regulation of This Process. Society for Investigative Dermatology Annual Meeting (2006) J. Invest. Derm. 126, S4, P.69.

(my latest CV and list of publications are available here)

Previous versions of homepage:

Columbia University, USA
Center for Radiological Research
(2005-2010)

New York Medical College,
Pharmacology
(2000-2005)

English/Русский

Latest Update was performed at January 19 2012 г.