It appears that in the case of Neferure being a direct heiress, her daughter(s) could not lose her status because her blood assured her positon. With any other wife that was elevated to queenship, she needed to produce a male heir. If she did not, there was no brother for that daughter to marry and this opened the way for next wife. Death had the none of these consequences on direct heirs. In egyptian royalty, the eldest son was heir. If he died before succeding his father, his children had no claim to the throne. The crown would pass to the next eldest surviving son.

Two daughter's of Thutmose, however, were not to be dismissed. The first was "Ahmose Meritamen". Although around 20+ years older then her spouse and half-brother, she became "great wife" for a year or so before passing away, probably childless. In order for her to have maintained her status throughout her lifetime [45], she had to be the daughter of an heiress. The only direct heiress he'd married was "Neferure".

Another daughter was Sitamen I, who was a probable sister or half-sister of Ahmose. She carried the title of "Gods Wife" in Amenhotep II's reign. With this queen, it is a bit difficult to surmise whom her mother was, though quite probably Neferure. She may still have been older then her husband, though not as excessively so as her predecessor. She was to produce the crown prince Amenhotep, and the heiress Yaret. Had Sitamen's status been less then royal, her daughter would not have become a chief queen. Yaret was briefly Thutmose IV's chief wife. This pairing may have produced Sitamen II, which recently started a controversy among egyptologists on exactly whom her father was. She was an heiress daughter. But was she a sister of Amenhotep III, being passed off as a daughter of Tiye? And did she become the mother of a king [Smenkhkare]?