The Games Factory
This is just one of many similar game making programs. It is also the best.
Anyone can use it. It will only take a week or two before you're ready to design full featured games. The full version is recommended as the demo cannot create exe files. However, if you send your game in the default '.gam' format, I'll turn it into a stand-alone application myself.

Multimedia Fusion (Demo)
Another game maker. It's just like Games Factory but has a FEW more features and is SO much more complicated. Games and sprites created on TGF are compatible with games on MMF. If you're a novice game creator, get The Games Factory. But if you're into advanced game creation, MMF may be right for you.

Install Maker Pro
Create an Install program for your finished games.