The Perpetual Help Anglo Chinese School was founded in September 1955 by the Redemptorist Fathers - Joao Campos Rodrigues and Eusebio Arnias at Estrada da Vitoria, 28. The Kindergarten and Primary School started with few pupils only. Two years later, registrations increased and six more classes were built; other classes were added in 1962. In 1964 another new building was constructed. This was blessed by Cardinal Don Jose da Costa Nunes, with the assistance of several bishops including Mgr. Caprio Apostolic Internuntius of Taiwan, on 9th December 1964.

In September 1964, the Secondary School was introduced for boys and the following year it was opened to girls too. In 1966, the school bought an adjacent house, but the Redemptorist Fathers left Macau in June 1967.
 

The school was taken in 1967 by the Society of Divine Love : a feminine institute founded in Macau by Fr. Eugenio Isamar (S.J.). The school's name was "Perpetual Help College".

In January, 1976 the Daughters of Mary Help of Christians became the owner of the College. It was named Daughters of Mary Help of Christians Perpetual Help College.

In 1986, Mr. Chan King Luen gave a donation to construct two new buildings for the school in memory of his father Chan Sui Ki. Since then, the school was named Chan Sui Ki Perpetual Help College.

In 1990. the Kindergarten Section moved to Travessa Dos Bombeiros, 9/G., under the name of Wing Wah School. In 1992, the school's name was changed to Chan Sui Ki Perpetual Help College (Suc.).