CURRICULUM VITAE
Updated December 3, 2004
Jeffrey A. Freed, M.D.
PLACE OF BIRTH: St.
Joseph, MO (12/10/59)
ADDRESS: 15805 27th Ave. NE
Shoreline, WA
98155-6440
PHONE:
206-365-5754 (home)
425-259-5141 (work)
253-230-6954 (cell)
EDUCATION:
Undergraduate: Carnegie-Mellon U., Pittsburgh, PA
B.S. in
Biology with University Honors, 1979
Medical: Jefferson Medical College,
Philadelphia, PA
M.D.,
1983
POSTGRADUATE
TRAINING:
Residency: Anatomic and Clinical Pathology
(1983-1987)
The Mount Sinai Hospital, New
York, NY
Fellowship: Blood Banking and Transfusion
Medicine (1987-1988)
The New
York Blood Center, New York, NY
PRACTICE
EXPERIENCE (16 years):
7/88 to 6/89:
Peekskill Community Hospital,
Peekskill, NY (now Hudson Valley Medical
Center):
Staff pathologist, anatomic and clinical
pathology
Director, blood bank
7/89 to 7/92:
St. Vincent Charity Hospital, Cleveland,
OH:
Staff pathologist, anatomic and clinical
pathology
Director, Blood bank and hematology
laboratories
Responsible for all bone marrow
biopsy/aspirate interpretation
Chairperson, Utilization Review Committee
Member, Clinical Monitoring and Quality
Management committees
Aspiration Biopsy Laboratory, Inc. (now
Oncor), Cleveland, OH:
Pathologist: interpreted 15,000 prostate
core biopsies
and aspiration
biopsies in 3 years, performed DNA ploidy
analysis personally
on 3000 prostate core biopsies
University Hospitals of Cleveland:
Clinical Instructor, hematology
8/92 to 4/95:
Physicians Clincal
Laboratories, Inc., Burbank, CA:
Pathologist
4/95 to 6/95:
Medical Science Laboratories, Burbank,
CA: Pathologist
7/95 to 8/96:
St. Francis Medical Center, Lynwood,
CA: Staff Pathologist
8/96 to 10/02:
Good Samaritan Hospital, Puyallup, WA: Joint
Medical Director of
Pathology and Laboratory Services (primary
responsibility in clinical lab);
Staff Pathologist.
5/99 to 7/02:
Clover Park Technical College (Lakewood, WA):
Medical Director of the MLT-C Training Program
9/02 to present:
Providence Everett Medical Center and
Associated Pathologists, Everett,
WA:
Staff Pathologist.
4/04
to present:
Medical Laboratory Associates, Seattle, WA:
Pathologist
Patan
Hospital, Patan, Nepal: Surgical pathologist, 7/12/99 to 8/7/99.
Tribuvan University Hospital, Katmandu, Nepal:
Guest lecturer to
pathology residents, 7/12/99 to 8/7/99.
BOARD
CERTIFICATION:
Anatomic and Clinical Pathology
(11/18/1987)
Blood Banking and Transfusion Medicine
(5/18/1988)
National Board of Medical Examiners
(1984)
OTHER
CERTIFICATES:
Basic Life Support with Automatic
External Defibrillator for Healthcare
Providers, Certificate # 39063, 8/20/02
to 8/20/04 (not current)
STATE MEDICAL
LICENSES:
Washington MD00034072
California G 63966
Alaska
No. 5405
Ohio 58404 (inactive)
New York 161868 (inactive)
PUBLISHED
JOURNAL ARTICLES:
1.
Maier M, Freed JA, Milz
S, Pellengahr C, Schmitz C. [Detection of bone
fragments in
pulmonary vessels following extracorporeal shock wave
application
to the distal femur in an in-vivo animal model.] Z Orthop Ihre
Grenzgeb
141(2):223-226, 2003.
2. Zybina TG, Kaufmann P, Frank H-G, Freed J, Kadyrov M, Biesterfeld S.
Genome multiplication of extravillous trophoblast cells in
human placenta
in the
course of differentiation and invasion into the endometrium
and
myometrium. I. Dynamics
of polyploidization.
Tsitologiia 44(11):
1058-1067, 2002.
3. Freed JA. Conceptual comparison of two computer models
of corpuscle
sectioning
and of two algorithms for correction of ploidy
measurements in
tissue
sections. Analyt
Quant Cytol Histol 22(1):
17-25, 2000.
4. Freed
JA. Improved correction of
quantitative nuclear DNA (ploidy)
measurements
in tissue sections. Analyt
Quant Cytol Histol
21(2):103-
112, 1999.
5. Freed
JA. Possibility of correcting image cytometric
DNA (ploidy)
measurements
in tissue sections: Insights from
computed corpuscle
sectioning
and the reference curve method. Analyt Quant Cytol Histol
19(5):376-386, 1997.
6. Freed
JA. Hypercoagulability: should every patient with
venous
thrombosis
be tested? Postgrad
Med 90(6): 157-166, 1991. [Review]
7. Freed
JA, Miller A, Gordon RE, et al. Desquamative
interstitial pneumonia
associated
with chrysotile asbestos fibres. Br J Ind Med
48(5):332-337,
1991.
8. Freed
JA, Pervez NK, Chen V, et al. Cutaneous
mycobacteriosis:
occurence
and significance in two patients with the acquired
immunodeficiency
syndrome. Arch Dermatol
123:1601-1603, 1987.
9. Freed
JA, Kaneko M, Gordon RE. Primary
angiosarcoma of the heart.
Mt Sinai J Med (NY) 53:301-304, 1986.
10.Pervez NK, Kleinerman
J, Kattan M, Freed JA, et al.
Pseudomembraneous necrotizing
bronchial aspergillosis. Am Rev
Respir Dis 131:961-963, 1985.
PUBLISHED
LETTERS AND ABSTRACTS:
DNA ploidy
analysis by image analysis. Bramwell NH, Freed JA.
Galang CF, Park
CH, Johenning P, Lanuza MR,
Freed JA, Bramwell NH.
Improved diagnostic yield from prostatic tissue core biopsies.
Value of
cytologic examination of fixative solutions and
aspirates. Lab Invest
62(1): A35, 1990. [Abstract]
More on the pros and
cons of directed blood donations.
Freed JA.
Transfusion 29(7):655-656, 1989. [letter]
PRESENTATIONS AT
MEETINGS:
Techniques of cytomorphometric
(nuclear DNA ploidy) analysis for paraffin
embedded
sections. Park CH, Galang
CF, Johenning PW, Tannenbaum
M,
Freed J, Bramwell N. Poster at 1990 American Urologic Association.
Improved diagnostic yield from prostatic tissue core biopsies: value of
cytologic
examination of fixative solution and aspirates.
Galang CF, Park
CH, Johenning P,
Lanuza MR, Freed JA, et al. Poster at International
Academy of Pathology
meeting. Abstract published in
Lab Invest 62:35A,
1990.
T-cell markers in tuberculous granulomas. Freed JA, Jagirdar J. Poster
at
March 1987 International Academy of
Pathology meeting.
RESEARCH:
1.
Began study of implementation of scientific statistical quality control
at
Good Samaritan
Hospital laboratory, Puyallup, WA (2002).
2.
Application of computer modeling to the evaluation of stereologic methods
in
collaboration with Dr. Med. Christoph Schmitz, RWTH
University of
Aachen,
Germany (1999-present).
3.
Creation of computer models of tissue sections and methods for
correcting
image cytometric ploidy measurements in
tissue sections, with applications
in
autoradiography and flow cytometry (1994-present).
4.
Study in prostate core biopsies relating proximity of coexistent PIN and
carcinoma to
ploidy of the respective lesions (St. Vincent Charity
Hospital,
Cleveland, 1991).
5.
Flow cytometric study of transfused platelet
survival in alloimmunized
recipients
(New York Blood Center, 1988).
6.
Study of autologous and directed donation
practices and policies at
university
hospitals and blood centers across the United States (New York
Blood Center,
1987).
7.
Set up Western Blot at Bronx VA Medical Center (laboratory of Neville
Colman, M.D.) for
detection of antibodies to HIV-1 in human sera, 1986.
8.
Study of the Na/K ATPase in thyroid tissue
challenged with cardiac
glycosides
(NIH Trainingship in the Medical Student Vacation
Research
Program (Grant
#2T35HL07497), 1981.
U.S. PATENTS:
"A general method for determining the
volume and profile area of a sectioned
corpuscle",
U.S. Pat. No. 5,918,038 issued 6/29/99 to Jeffrey A. Freed.
"Method for correction of
quantitative DNA measurements in a tissue section",
U.S. Pat. No. 6,035,258
issued 3/7/00 to Jeffrey A. Freed.
“Use of perimeter measurements to improve
ploidy measurements in a tissue
section”, U.S.
Pat. No. 6,603,869 issued 8/5/03 to Jeffrey A. Freed.
GRANTS:
Co-investigator, START grant from the RWTH
University of Aachen, Germany
(principal
investigator: Christoph
Schmitz) for “Quantitative Cellular Human
Brain Mapping” ($200,000).
MEDICAL
DIRECTORSHIPS:
Good Samaritan Hospital: Joint Medical Director of Pathology and
Lab
Services (1996-2002), with primary
responsibility for laboratory but with heavy
pathology
involvement.
Clover Park Technical College: Medical Director, MLT-C program (1999-
2002).
St. Vincent Charity Hospital: Director of Blood Bank and Hematology
Lab
(1989-1992).
Peekskill Community Hospital: Director of Blood Bank (1988-1989).
TEACHING SINCE
RESIDENCY:
RWTH University of Aachen,
Germany: Gave an invited lecture,
"A new method for
correcting ploidy measurements in tissue
sections" (1999).
Good Samaritan Hospital, Puyallup: Gave medical grand rounds on
"Appropriate Blood
Utilization" (1996).
Presented pathology at
Tumor Board (in rotation).
St. Vincent Charity Hospital,
Cleveland: Gave medical grand
rounds:
Criteria for Transfusion (1989) and Workup
of the Hypercoagulable
State (1991).
Presented pathology at
Tumor Board (in rotation).
Case Western Reserve University School
of Medicine: Taught
hematology lab
to medical students (1991).
New York Blood Center: Presented required lectures at the
"Advanced
Seminar in Blood
Banking". Presented
in-service lectures to reference lab
technologists
(1987-1988).
TEACHING AT MOUNT SINAI SCHOOL OF MEDICINE:
Current Problems in Autopsy Pathology PAT
053: Instructor responsible for
course content
and presentation, 1986.
Pathology--The Language of Disease PAT
095: Assistant instructor, 1986.
Required teaching of laboratory section in
the second year pathology course,
1983-1987.
Instructor to first-year pathology
residents at Elmhurst City Hospital, Queens,
in autopsy, 1985.
Radiology Department pathology correlation
conference: Responsible for all
pathology
presented, 1986-1987.
Required presentation of pathology at
Medical Mortality, Surgical Mortality,
and various Pathology Department conferences, 1983-1987.
PROFESSIONAL
ORGANIZATIONS:
U.S. and Canadian Academy of Pathology
College of American Pathologists
(Fellow-Inspector)
American Society of Clinical Pathology
(Fellow)
California Society of Pathologists (past)
American Association of Blood Banks (past)
American Red Cross Medical Advisory
Committee (Cleveland, past)
Cleveland Blood Bankers' Breakfast Club
(past)
Cleveland Society of Pathologists (past)
ADMINISTRATIVE
ACCOMPLISHMENTS:
Began process of setting all chemistry and hematology statistical
quality
control on a firm
scientific foundation based on Westgard at Good
Samaritan Hospital, Puyallup, WA (2002).
Revised surgical pathology accession forms
and frozen section
documentation at
Good Samaritan Hospital, Puyallup, WA (2001).
Introduced several new tests at Good Samaritan Hospital, Puyallup,
WA:
Troponin I, Fetal fibronectin, SimpliRed D-dimer, PFA-100 (1998-2002).
Created and put through committee a
massive transfusion protocol at Good
Samaritan Hospital, Puyallup, WA (2000).
Comprehensively revised and put through
committee a new critical values list
at Good Samaritan
Hospital, Puyallup, WA (1999).
Created and implemented a prospective
transfusion auditing program at St.
Vincent Charity Hospital (Cleveland)
resulting in a decrease in the rate of
inappropriate
transfusions of platelets and red cells from 25% to 5% of
transfused units
(April 1990).
Comprehensively revised and put through
committee transfusion audit criteria
at St. Vincent
Charity Hospital (Cleveland, 1990).
Created and implemented autologous and directed donation policy and
procedure at
Peekskill Community Hospital (1988).
Helped to develop a new autologous and directed donor policy for The New
York Blood Center
(1988).
HOSPITAL
COMMITTEE WORK AT ST. VINCENT CHARITY HOSPITAL, CLEVELAND:
Clinical Monitoring Committee: Reported transfusion practices and anatomic
pathology QA data
on a monthly basis.
Utilization Review Committee: Voted Chairperson Jan. 1992. I was also the
principal
physician reviewer of inpatient length-of-stay and admissions.
Quality Management Committee: Reported on activities of the Utilization
Review Committee.
Trauma Committee: Blood bank liason.
HOSPITAL
COMMITTEE WORK AT GOOD SAMARITAN HOSPITAL, PUYALLUP:
Chair, Committee on
Blood Utilization.
Chair, Infection Control
Committee.
Member:
Executive, Adult Medicine, OB/GYN, Performance
Improvement, and
Medical Informatics committees.
TECHNOLOGICAL
EXPERIENCE:
Image analysis
Flow Cytometry
Western Blot
Computer modeling
INTERESTS AND
AREAS OF CONCENTRATION:
Laboratory management
General surgical pathology
Prostate biopsy interpretation (core and
FNA)
Bone marrow aspirate/biopsy performance
and interpretation
Laboratory hematology and coagulation
Cytopathology: Gyn and non-gyn, can perform FNA
Blood banking and transfusion medicine
Statistics
Computer modeling