The Butcher (Single/Multiplayer)
Given From: The Wounded Townsman.
Quest Summary: First find the room with the Butcher in it. It should be a room on Level 2 with many slain bodies inside. If you are a Warrior, obtain a shield, a sword, some leather armor, and many healing potions on your belt. Open the door and let him come to you. When he gets close to you, try to get off the first hit. With luck, you should be able to pummel him to death with your sword while taking minimal damage. If you are a Rogue, open the door and run back. Hit and run while firing arrows into him until he dies. If you are a Sorcerer, open the door and make sure he sees you Cast a Flame Wall spell in his chamber, then shut the door. He should succumb to the flames. After he dies, pick up the Butcher's Cleaver, a unique item.
Hint: Clear out the level of monsters first. Before you open the Butcher's door find a room that has a door (that is not blocked) and a grate that you can shoot / spell through. After opening the door, run away to this room and CLOSE THE DOOR. The Butcher can't open it, but he will stand there and let you shoot at him through the grate!
Poisoned Water Supply (Single Player)
Given From: Pepin.
Quest Summary: When you start a new game and the water in the fountain behind Cain is yellow, then you're going to have this quest. When you hit Level 2 of the dungeon, come back to town and talk to Pepin. He should tell you that he water of Tristram is going bad, and that it's up to you to figure out what is going on before people become sick and die. Go back to Level 2 and look for a hole in the wall surrounded by candles. When you find this hole (says "To a Dark Passage") enter it. Inside you should find Goatmen, Dark Ones, and other enemies. Defeat all the enemies in the Dark Passage, and the quest will be solved. Return to Pepin and he will give you the Ring of Truth as your reward.
The Skeleton King (Single/Multiplayer)
Given From: Ogden.
Quest Summary (Single Player): After speaking to Ogden who will solicit your help to put King Leoric's soul at ease, enter his tomb on the third level. Within the tomb you should kill all the enemies, then approach the two levers. Switch the lever on the left (east room) to open a door to a room with a couple of chests. Check the chests for useful items inside. Once you do that, go back an switch the lever on the right (west room) to open the way to the Skeleton King. Try to get to the Skeleton King as quickly as possible to kill him, for he will resurrect other skeletons if you attack them first. Holy Bolt works nicely on him, and hand to hand combat with him could prove to be fatal.
Quest Summary (Multiplayer): Leoric is on the third level of the dungeon. He isn't in any special room or anything. Just wander around the level, and eventually you will find him. He is protected by a lot of skeletons. If the skeletons are archers, then run for your life! They will wear your life down very, very fast. Just let Leoric come to you. He isn't very easy to beat, especially with a sword. Make sure that you have a good weapon, some good armor, and a toolbelt full of healing potions. One good thing is that he doesn't resurrect the skeletons.
Ogden's Sign (Single Player)
Given From: Ogden
Quest Summary: When Ogden informs you that his sign to his tavern is missing, go down to Level 4 and search for a Dark One named Snotspill. He will inform you that some "big uglies" stole his sign, and that he wants it back. Search around Level 4 for a room with many Overlords and a chest inside. Open the chest to retrieve Ogden's sign. From this point, you can solve the quest via two methods. The first is to give the sign back to Snotspill. He will say that he can now cast great magic, and will ambush you with Dark Ones. Or, you can go give Ogden back his sign and get a magical item as a reward.
Garbad the Weak (Single Player)
Given From: Garbad the Weak.
Quest Summary: Venture into Level 4, and you will meet Garbad the Weak. He will tell you that if you protect him from the enemies in the dungeon, he will give you a great reward. After he tells you this, go off somewhere else in Level 4. Return to him, he will now tell you he is still making your reward and will give you an item in the meantime. Leave him alone for a while then return to Garbad a second time, when he will tell you he is not yet done. Leave one last time. Upon return to Garbad, and he will say that he has finished the item, but you must fight him for it. He is easy to kill, and when you do, pick up the random item he was making.
Arkaine's Valor Armor (Single Player)
Given From: Book of Blood
Quest Summary: In Level 5 of the catacombs you will find a book which will speak of the warrior Arkaine, and will tell that his armor called Valor resides somewhere in the Catacombs. Search the catacombs for a blood altar and three blood stones. Pick up all three blood stones and place the in the blood altar (just click on the altar once to place a stone). When this is done, a wall will disappear and a great hall will be before you. Continue down the hall, killing all the demons that attack you. At the end of the hallway you will find Arkaine's Valor Armor.
Chamber of Bone (Single Player)
Given From: Book
Quest Summary: In the Catacombs you will find a book on a pedestal. This will tell you of great treasures found in the Chamber of Bone. Now look for a new area revealed or a staircase surrounded by eight pillars. Go up the staircase. In the chamber there will be two levers one to the left and one to the right. First kill all the enemies (Firewall is good here). Once the levers are pulled they will reveal rooms containing magical goodies. Return to the original chamber, at the end of the room and read the Guardian Spell Book.
Given From: Griswold
Quest Summary: After you enter the catacombs (Level 5), return to town and talk to Griswold. He will speak of the Magic Rock which he has heard of. If you return it to him, he will give you a reward. Return to the catacombs and search for the Magic Rock. Once you find it, return it to Griswold and receive the Empyrean Band.
Halls of the Blind (Single Player)
Given From: Book of the Blind
Quest Summary: Read this book to recite a poem about the Halls of the Blind. After you read it through, you will be able to access a room which you couldn't access before. Enter the room and search one of the adjacent rooms for the Optic Amulet. Once you find it, this quest has been completed.
Given From: Zhar the Mad
Quest Summary: In Level 8 of the catacombs, you should encounter Zhar the Mad in a library. Talk to him, and he will give you a book to keep you busy while he goes about his work. Take the book and all the scrolls around you, but do not take the book from the bookcase. When you feel you are ready to fight him, take the book from the bookcase. Zhar will get mad that you have done this, and will fight you. He will teleport around the room and shoot fireballs with his staff, making him very hard to get a hit on him without being hurt yourself. To make this much easier, Stone Curse him when he is visible to get some easy hits on him. One or two Stone Curse spells, and he should be dead for sure. Another way to kill him, like any magician, is to get him into the corner. He will disappear but will reappear in the same spot.
Black Mushroom (Single Player)
Given From: Fungal Tome
Quest Summary: Search the caverns for a Fungal Tome. Once you find it, go to town and talk to Adria. She will tell you that in order to make use of it, she will need a Black Mushroom. Return to the caves and search for a patch of mushrooms within. Take the Black Mushroom and return to Adria with it. She will say that she now needs an elixir from Pepin. Ask Pepin for the elixir, and he will say that he will need a demon's brain to create such an elixir. Return to the caves and kill any demon. His brain will pop out. Grab it and return to Pepin for the elixir. Go back to Adria with the elixir, and she will say that she does not need it any more. Drink the elixir to raise your all your base stats by two or three.
Given From: Griswold
Quest Summary: After you enter deep into the caves, return to town and talk to Griswold. He will speak of the Anvil of Fury which he has heard of, and will tell you that if he has this anvil, he can craft you a truly powerful weapon. On Level 10 of the caves, out on a peninsula of land which stretches into the lava, you will find the Anvil of Fury. It will be surrounded by archers. Kill them all and collect the Anvil and take it and return to Griswold for Griswold's Edge, a very good sword.
Warlord of Blood (Single Player)
Given From: Steel Tome
Quest Summary:Later in the game you will find a Steel Tomb that talks about the Warlord of Blood. Proceed down to Level 13 to find him. He will be in a room guarding the entrance down to Level 14 along with a few other Blood Knights. To kill him easily, lure out each of his escort Blood Knights one by one. With time and patience, you should be able to lure most of them out without provoking the Warlord to come after you. When you feel that you are ready, get close to him and retreat. He should follow you. Exit the room which he is in to give yourself some space, then fight him to the death. After you kill him, enter back into the room he was in to get some cool armor and weapons. When you have collected all the items that you want, go on down to Level 14.
Given From: Lachdanan
Quest Summary: Find Lachdanan on Level 14 and talk to him. He will not attack you, and will explain his story of how he was once one of King Leoric's Knights until a curse came upon him. He is the only one of the Blood Knights which has stood the curse and kept his sanity, and requests that you find him a golden potion so he can end his life without being eternally damned. Head down to Level 15 and search for this potion. Once you find it, return to Lachdanan and give it to him. He will give you give you the Veil of Steel and, after he kills himself, he will drop a magical item for your use.
Archbishop Lazarus (Single/Multiplayer)
Given From:Cain
Quest Summary (Single Player): Search Level 15 until you find the Staff of Lazarus. Once you find it, pick it up and head back to town with it. Talk to Cain, and he will notice the owner of the staff and explain to you how Lazarus must be killed at this point of time. He will take the staff from you and send you on your way. Head back down to Level 15 and you will find a red portal near the marble pentagram. Enter the portal to enter Lazarus' lair. Once you enter his lair, proceed to go through it killing all the Hell Spawns and other enemies you find. Once you have cleared out all the enemies you can find, go search for a gray circle on the ground (there should be two or three). Enter it, and you will be in an area where some Hell Spawns were. Enter the other gray circle, and you should be in another area where Hell Spawns were. Now retreat to where you started the level at. A third gray circle should be on the ground. Enter it to go straight to Lazarus. After the cut scene of him, you should start off in a room with Lazarus and many Hell Spawns. Lazarus will be talking, and the Hell Spawns will just be sitting there. Take this point in time to run down the hall. When he is done talking, the Hell Spawns will come after you little by little. Kill them off until only Lazarus is left. Find Lazarus, and kill him to complete the quest. Stone Curse works nicely on him if you can't get him to hold still... A hint is to beat on Lazarus while he is talking...he won't move. Or you can use the same strategy you used against Zhar the Mad. Just get him into a corner and kill him.
Quest Summary (Multiplayer): Once you get down to level 14, go back to Cain. He will give you the quest. Then go down to level 15. Level 15 looks the almost the same as Lazarus's lair on Single Player. You can tell which room he is in because there are three spots that are lit up on the floor. There will be Advocates, a few Hell Spawns, and two special Succubi, Black Jade and Blood Lust.. Try to lure everyone but Lazarus out of the room. After killing them go in and fight Lazarus. You can use Stone Curse on him, or you can get him in the corner and kill him.
Given From: Cain
Quest Summary: After you have killed Lazarus, head back to Cain in town. He will now tell you of the quest of Diablo, Lord of Terror. Retreat back down to Level 15, and walk into the pentagram to enter his lair. To make this level very simple, fight your way down to the lower-left hand corner of the map. There you should find an enclosed room, with many enemies and monsters scattered around it. Kill them all, and ready a spell or scroll of Telekinesis. Inside the room you should be able to see two levers. Both must be pulled in order to open the room with Diablo in it. Use Telekinesis to pull them both. Then head down to the lower-right hand corner of the level. You should find Diablo there along with many other enemies. Try to lure just Diablo out of the room. Once you do, lead him to some other part of the level away from all other monsters. Once it's just you and him, go in for the kill. Another recommend method is to clean out all the other minions accompanying him, then go one on one.