If you are coming from the San Antonio Airport or from the North part of the city, take 281 south and take the Durango Street/Alamodome exit. 

If you are coming from Austin, take 35 south to 281 south and take the Durango/Alamodome exit. 

If you are coming from the south part of the city, take 37 north which turns into 281 north and take the Durango Street/Alamodome exit. 

If you are coming from Houston take 10 west to 281 north and take the Durango Street/Alamodome exit.