Mouse Hepatitis Virus (MHV) is a member of Coronaviridae. It is an enveloped virus and can
cause wide range infection in animals as well as human being. MHV has a 32K nucleotides-long
single stranded, positive sense RNA genome, which makes MHV the largest RNA virus. An
unique discontinuous transcription strategy is used by MHV to produce seven species of single
stranded mRNAs, including genome RNA, in MHV infected cells. These mRNAs comprise a
3'-coterminal nest set of mRNAs with same leader sequence at 5' end, missing different length
of region following the leader sequence on genome.

My dissertation research in Medical College of Ohio is focus on the study of  replication/transcription
of MHV. But I also have a lot of experience in virus binding, entry and assembly assay.

Attached documents briefly summarize my work on:

1). DEAE-dextran's effect on virus infectivity and its mechanism (presented in the Third Cleveland
Virology Symposium, Ohio); >>> abstract
2). Stability and turning over of MHV replication intermediate/replication form (RI/RF) RNA
(presented in the VIII International Symposium on Nidoviruses, Pennsylvania); >>> abstract
3). Unstable character of MHV RI/RF RNA at 4°C (presented in the American Society for Virology
2000, 19th Annual Meeting, Colorado); >>> abstract
 

Abstracts or brief summaries are provided and details are available upon request.