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MARIA OF THE PILLAR YAG�E, R.N.
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| THE DISCOVERY OF THE SUBSTANCES ANTIPSIC�TICAS OR NEUROL�PTICOS |
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MARIA OF THE PILLAR YAG�E, R.N.
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PSYCHOSIS: ESQUIZOFRENIA
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EXAMPLES OF MENTAL DISTURBANCES IN THE ESQUIZOFR�NICOS: TO THINK AND TO BELIEVE AT THE SAME TIME OPPOSITE THINGS - " She did not had handkerchief, she were stopped the mouth with their/its/your/his handkerchief " -. - " I Am a human being as you, though I do not am a human being " -. |
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DISCOVERY OF THE FIRST ANTIPSIC�TICO
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DISCOVERY OF THE MECHANISM OF ACCI�N OF THE ANTIPSIC�TICOS
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CEREBRAL MAP OF THE RICH NEURONS IN DOPAMINA
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These 4 drawings are of the painter Louis Wain that to 57 years began to express symptoms psic�ticos.El deterioration of their/its/your/his mental health is put clearly of I manifest in the progressive breakup of their/its portraits of gatos.Tambi�n the painter VanGoht suffered a esquizofrenia. The esquizofrenia is one of the diseases psic�ticas but serious and devastadoras that are known in the patologia human. The sick esquizofr�nicos suffer illusions totally detached from the reality (believe be Napole�n or other famous person). On the other hand they suffer hallucinations or perceptions of things that they do not be present in the environment that you/them surrounds. Though the hallucinations can affect to anyone of 5 senses it but frequent is that will be of type auditivo.La mayoria of these sick hear voices that you/them atormentan.En some occasions these patients have been committed suicide or assassinations assignment obeying the orders of these voces.Estos sick believe that someone or some strange forces have inserted to him/her/you in the head those thinks
In 1951 the French psychiatrists Jean Dealy and Pierre Deniker began to administer the clorpromacina to progressively growing dose to sick esquizofr�nicos observing a notable mejoria in these patients.
In 1972 Paul Greengard demonstrated that the medicines neurol�pticos or antipsic�ticos (in green) are joined and blocked the receivers of dopamina in the neurons postsin�pticas, preventing that the transmitter dopamina is an or couple with these receivers and by so much inhibiting or reducing the transmission of the nervous impulses of caracter dopamin�rgico in the system l�mbico.
The rich neurons in dopamina (blue) are grouped in the call kernels of the tegmento.Las prolongations (axones) of these neurons establish connections (sinapsis) with the system l�mbico.Volvemos to recall that this system regula,modula and controls our emotions. We have seen previously that habia a group of rich neurons in noradrenalina (system noradren�rgico) that determine an action energize you. Also there is other group of rich neurons in serotonina (system serotonin�rgico) that produces a general welfare state. Finally there is a group of rich neurons in dopamina (system dopamin�rgico) commissioned with maintaining our thinks and perceptions according to the reality of the middle that us rodea.Posiblemente without an adequate operation of the system dopamin�rgico seriamos unable to distinguishing that perceptions agree with the real world and what are product of our cavilaciones.Es to say this system dopamin�rgico serves to separate - " the wheat " - from the - " straw " - ..Cuando this system is altered as happens in the esquizofrenia and other psychosis appear symptoms as the delirious ideas and the hallucinations.