Technology
2/25/00
Batteries have had their chips
2/24/00
- First diamond micro-machine takes a bow
2/1
- RNA computer clears 10-bit hurdle


BBC 2/25/00
Friday, 25 February, 2000, 12:32 GMT
              Batteries have had their
              chips

 
              By BBC News Online science editor
              Dr David Whitehouse

              Scientists at Cambridge University
              say they have developed a new
              generation of magnetic microchips
              that may herald the beginning of
              faster, more efficient computers and
              electronic devices.

              Researchers say that the chip stores
              data in the form of tiny magnetic
              fields and that versions of the chip
              currently being tested are up to
              40,000 times more efficient than the
              electronic chips in use today.

              Dr Russell Cowburn said the chips,
              which he and colleague Professor
              Mark Welland have developed at the
              University's Department of
              Engineering, were likely to
              revolutionise the manufacture of
              microchips.

              In a paper published in the journal
              Science, Dr Cowburn describes the
              advantages the new chip has over
              existing technology.

              "There are two big differences
              between our chips and others. The
              first is size: most existing electronic
              chips can fit up to 6.6 million
              transistors (the basic building blocks
              of all microchips) into one square
              centimetre.

              "But we have demonstrated a device
              that can fit 5,500 million transistors
              into a similar area. We estimate in
              future years this could increase to
              250,000 million transistors."

              "The other big advantage is energy
              consumption. Electronic chips use up
              energy during operation, whereas a
              magnet does not."

              "That means computers developed
              using magnetic microchips will need
              much less power to work. The days of
              carrying around heavy batteries for
              laptop computers and mobile phones
              are numbered!"

              Professor Welland added that it
              would be several years before the
              new technology could be developed
              commercially, but he said a
              completely new type of computer
              would be made using this method

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BBC 2/24/00
Thursday, 24 February, 2000, 16:36 GMT
              First diamond
              micro-machine takes a
              bow
 

              Scientists at the US Department of
              Energy's national security facility
              have created a micro-machine etched
              from amorphous diamond, the
              hardest material in the world after
              crystalline diamond.

              The methods used were the same as
              those used with current silicon chip
              manufacturing techniques.

              The first diamond micro-machine is a
              comb drive whose tiny teeth move
              forward and back as an electrical
              current reverses constantly between
              positive and negative. The teeth are
              just two thousandths of a millimetre
              apart.

              The researchers, at the Sandia
              National Laboratories in New Mexico,
              say diamond has a number of
              valuable properties.

              Resistant to wear

              Its resistance to wear makes
              diamond ideal for micro-machines
              that need to function for extended
              periods of time.

              "One estimate in the literature claims
              that diamond should last 10,000
              times longer than polysilicon," said
              group member Tom Friedmann.

              Also, diamond is
              less susceptible
              to "stiction" than
              silicon. Stiction -
              a combination of
              stickiness and
              friction - can
              render
              micro-machines
              useless. This is because silicon is
              attracted to water, which acts as a
              kind of glue. Diamond does not have
              the same problem.

              Another advantage is that diamond is
              biologically benign. A micro-machine
              such as a tiny drug dispensing unit
              could be used in the body without
              triggering an allergic reaction.

              There are two kinds of diamond,
              crystalline and amorphous. The
              Sandia researchers used amorphous
              diamond because crystalline diamond
              needs far higher temperatures to
              synthesise it, and also its surface
              roughness makes it unsuitable for
              micro-machines.

              Amorphous diamond itself had been
              impractical because its tremendous
              internal stresses had made it
              impossible for the material to stand
              alone or to coat thickly any but the
              strongest surfaces.

              However, a process developed by
              Friedmann and Sullivan eliminated
              that problem.

              Silicon MEMs (MicroElectroMechanical
              Systems) are already used in a
              variety of applications, ranging from
              air bags in cars to optical
              micro-mirrors intended for possible
              deployment on satellites.

              It's hoped that diamond MEMs could
              eventually offer a harder wearing and
              more flexible alternative, and in the
              future could replace silicon
              micro-machines completely.
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CMPnet 2/1/00

RNA computer clears 10-bit hurdle

By R. Colin Johnson
EE Times
(02/01/00, 11:05 a.m. EST)

PRINCETON, N.J. ; Princeton University researchers claim to have
reached a new level of complexity in DNA computing. The group has
demonstrated an RNA-based computer capable of solving mathematical
problems that were encoded as 10-bit strings.

Strands of RNA containing 1,024 base pairs were encoded with every
possible solution to a specific chess problem. Ribonuclease digestion
progressively narrowed down the possible solutions until only the 43
correct solutions ; plus one incorrect one ; remained.

"Molecules can store more information than silicon chips, and this was
the largest problem ever solved by a molecular computer ; using
either DNA or RNA. We also learned how far we can push this technology
when we discovered why it made a single error," said professor Laura
Landweber, the leading Princeton researcher on the project.
Landweber's colleagues are professor Richard Lipton and post-doctorate
candidates Dirk Faulhammer and Anthony Cukras.

[INLINE]

In 1994, Leonard Adleman of the University of Southern California-Los
Angeles conceived of harnessing DNA to solve tough computation
problems. He demonstrated his concept on the classic seven-city
traveling-salesman problem using the base-four encoding of DNA. After
synthesizing trillions of DNA strands to stand for every possible
solution, his test tube finally came to the correct conclusion after
about a week.

Tough combinatorial problems like that chosen by Landweber's Princeton
team present significant hurdles to any finite-size computer. The
possible solutions to such problems expand so fast, Adleman reasoned,
that even a few variables will result in a problem so complex that
only approximate solutions can be found.

Toy-sized problem

The Princeton research team's problem was toy-sized, having a mere
1,024 possible solutions, but the group claims the basic nature of the
single error indicates that it can be scaled up to real-world-size
problems. Apparently, the error came from a rare source that will not
increase geometrically with the higher-dimensional solution spaces of
real-world problems.

"We just had a bit of bad luck ; or more literally two bits,
since it was two single-point errors in a row that foiled our
algorithm," Landweber said. "Two errors in a row are exceedingly rare
and shouldn't become a problem when we scale up."

The Princeton team substituted RNA for DNA to enable the use of a
universal enzyme that targets any part of a molecule. DNA has only a
limited set of restriction enzymes, so scientists may not be able to
cut the molecule where they want. The group demonstrated that its
streamlined approach using RNA could inherently scale up to
real-world-size problems by virtue of the universal enzyme.

Using a combination of binary RNA libraries and ribonuclease
digestion, the Princeton team created a destructive algorithm that
acts as a "universal restriction enzyme" ; a kind of molecular
scissors that can selectively cut out any specified strand for
digestion (removal). The thermostable reaction proved impervious to
single-bit errors, ensuring the fidelity of the hybridization.

Since the algorithm (by virtue of its universal restriction enzyme)
operates in parallel on every molecule in the test tube, it can make
trillions of parallel computations theoretically possible. In the
Princeton test, for example, it took only a series of five steps to
target all of the enzymes that slashed away those coded strands that
represented the incorrect solutions.

Knight moves

The particular problem posed to the RNA computer was how many ways
there are to place knights on a chess board so that none can take any
other. A 3-by-3 chess board was chosen so that each of its nine
squares could represent a bit in the RNA strand. A 10-bit library of
RNA strands gave a 1-bit buffer, used to correct 1-bit errors
chemically.

There were a total of 43 correct solutions among 512 total
possibilities; the RNA computer found all 43 correct ones and one
incorrect one.

For the future the Princeton team intends to go after problems that,
while not yet approaching real-world proportions, scale beyond the toy
category. "The class of general satisfiability, where we got this
chess problem, is naturally extendible. We might go to larger boards
or different variations on the chess problem," said Landweber.

Landweber's department, evolutionary biology, tracks the biological
evolution of species, including that of biological computers. Her
particular take has been to apply evolutionary biological principles
to what she calls molecular evolution.

"I want to trace the evolution of the molecules themselves from their
earliest emergence up to the complex organic molecules of today. In
molecular evolution it was the correct solutions to biological
computations that had a better chance at survival," said Landweber.

Her aim is to identify the component molecules, along with their
mutual reactions and their interrelationships, that have evolved to
create the biological computer called the human brain. Armed with the
correct molecules and their known reactions, previously intractable
problems could turn out to be child's play for trillions of
parallel-processing molecular computers.
 

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