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Resume
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Home address
1480, 46th Street
Los Alamos, NM 87544, USA
Phone: ++1 (505) 661-6867
Email: [email protected]
Work address
Bioscience Division (B-s1), MS 535
Los Alamos National Laboratory
Los Alamos, NM 87545, USA
Phone: ++1 (505) 667-0041
Fax: ++1 (505) 665-4637
Email: [email protected]
EDUCATION
1997 Ph.D., with the Highest Distinction Level, in Automatic Control and Digital Signal processing, The National Polytechnic Institute of Lorraine (INPL), France.
Thesis titled "In vivo light induced fluorescence and autofluorescence spectroscopy: instruments, analysis and modeling. Applications to the diagnosis of early cancers and the optimization of photodynamic therapy".
Supervisors:
- Professor H. Begorre, CRAN-EESTIN, Nancy, France.
- Professor F. Guillemin, Alexis Vautrin Cancer Centre, Vandoeuvre, France.
1996 Inter-Universities European Diploma in Medical lasers (DIUE), University of Nancy I, France.
1993 MS (Diplome d?etude Approfondie, DEA) in Automatic Control and Digital Signal Processing, The National Polytechnic Institute of Lorraine (INPL), France.
Dissertation titled "Methods and experiments for the determination of the total attenuation coefficient of light in biological tissues".
Supervisor: Professor E. Yvroud, CRAN-ENSEM, Vandoeuvre, France.
1989 BS, with Good Rate, in Electronics Engineering, Tichreen University, Syria.
PROFESIONAL & RESEARCH ACTIVITIES
1999- Postdoctoral Research Associate, Biomedical optics (B-S1), Biosicence Division, Los Alamos National Laboratory, NM 87545. Development of holographic and speckle interferometry systems for medical applications (Optical imaging of neural activities; detection of neural deformation as response of nerve excitation). Development of a spectroscopic system based on fiber-optic probe for performing combined measures of light elastic scattering and fluorescence spectra for human tissue diagnosis.
1998-1999 Assistant Professor, Department of Engineering, Al-Ahliyya Amman University, P.O.BOX: 975, Amman 19328, Jordan. Courses: Digital Signal Processing, Electronics (S.C. physics to Op. Amp.), Electronics Labs, Electrical Circuits Labs.
1997-1998 Postdoctoral Research Student, Research Center in Automatic of Nancy (CRAN), Laboratory of Automated Medical Instrumentation in Cancerology, 54511 Vandoeuvre-l�s-Nancy, France.
1993-1997 Ph.D. Research, Research Center in Automatic of Nancy (CRAN), INPL, France. Development of a spectroscopic system based on fiber-optic probe. Application of the developed system to the detection of biological tissue autofluorescence and the analysis of the pharmacokinetics of the photosensitizers employed in photodynamic therapy. Development of a Gaussian model for the reconstruction of the fluorescence spectra with its further application for the identification of the endogenous fluorophores participating in tissue autofluorescence and the determination of spectral discrimination criteria between normal and pathological tissues. Design of tissue phantoms simulating both autofluorescence and tissue optical properties. Determination of the influence of the fluorescence re-absorption by the hemoglobin on the detected spectra. Experience in vivo and ex vivo on animal models and on patients.
1992-1993 MS Research, Research Center in Automatic of Nancy, INPL, France. Study on the optical properties of tissue: light global attenuation, absorption and scattering. Application of the Beert-Lambert law and Kublka-Munk model for the determination of the optical coefficients of tissue. Experiments realized in vivo and ex vivo on animal models.
1989 BS, six months training, Electronics and Telecommunication Laboratory, Faculty of Electricity and Mechanical Engineering, Tichreen University, Syria. Analysis of the concept and development of a high frequency modulator applied in telecommunication.
LANGUAGES
Arabic and French: Bilingual
English: Fluent, both written and oral
AWARDS AND HONORS
1996 Won the Young Researcher Prize (Prix Jeune Chercheur) of the French Society of Medical Lasers (SFLM), France
REFERENCES
- Professor I. Bigio, Biosience Division (B-2), MS: E535, Los Alamos National Laboratory, Los Alamos, NM 87545, USA, Phone: ++1/(505) 667-7748
- Professor F. Guillemin, Alexis Vautrin Cancer Centre, Avenue de Bourgogne, 54511 Vandoeuvre-l�s-Nancy, France, Phone: ++33/3 83 59 84 00
- Professor H. Begorre, CRAN-ESSTIN, Parc Robert Bentz, Rue Jean Lamour, 54500 Vandoeuvre-l�s-Nancy, France Phone: ++33/3 83 50 33 33
- Professor Emeritus E. Yvroud, CRAN-ENSEM, 2 Avenue de la For�t de Haye, 54516 Vandoeuvre-l�s-Nancy, France Phone: ++33/3 83 59 59 59
PUBLICATIONS
Please refer to the list of publications enclosed herewith.
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LIST OF COMMUNICATIONS AND PUBLICATIONS
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[1] O. A'Amar, F. Guillemin
� Clinical demonstration of autofluorescence spectroscopy for the identification of tissue pathologies �, Advances in Optics for Biotechnology, Medicine and Surgery, United Engineering Foundation Conference, Kailua-Kona, Hawaii, USA, 1-6 August 1999.
[2] E. Bossu, J.-J. Padilla, O. A'Amar, R.M. Parache, D. Notter, C. Vigneron, F. Guillemin.
� Determination of endogenous porphyrins and the maximal HpD tumor/normal skin ratio in SKH-1 hairless mice by light induced fluorescence spectroscopy�, Artificial Cells Blood Substitutes and Immobilization Biotechnology, Vol. 27, No. 2, pp. 109-117, 1999.
[3] H. Rezzoug, O. A'Amar, L. Bezdetnaya and F.Guillemin, ?In vivo pharmacokinetics and photodynamic effect of Foscan� (mTHPC) in tumor tissue of mice bearing human colon adenocarcinoma?, Internet Photochemistry & Photobiology, Web site:
http://www.photobiology.com/v1/rezzoug/pub.htm.
[4] F. Guillemin, O. A'Amar, H. Rezzoug, J.J. Padilla, , L. Bezdetnaya, M. Barberi-Heyob, J-L. Merlin. � Pharmacocin�tique de la m-THPC au cours de la th�rapie photodynamique (PDT)- Spectrom�trie de Fluorescence �. M�decine & Chirurgue Digestives. 27-32, 1998.
[5] Padilla J.J., A'amar O., Guillemin F.
� La normalisation en spectroscopie de fluorescence tissulaire �, SFLM XVII� congres,Les Arcs 1800, France, 1998.
[6] H. Rezzoug, L. Bezdetnaya, O. A'Amar, M. Barberi-Heyob, J-L. Merlin, F. Guillemin
�Parameters affecting photodynamic activity of Foscan� or meta-tetra (hydroxyphenyl) chlorin (mTHPC) in vitro and in vivo �, Lasers in Medical Science, Vol. 13, No. 2, pp. 119-125, 1998.
[7] O. A'Amar, H. Rezzoug, J.-J. Padilla-Ybarra, L. Bezdetnaya, F. Guillemin
� Light induced fluorescence spectroscopy (LIF) in vivo and in clinics: pharmacokinetic and photobleaching measurements with Foscan� (mTHPC) �, The 7th Biennial Meeting of the International Photodynamic Association, Nantes, France, RC202, ref. 205, 103, 7-9 July 1998.
[8] O. A'Amar, F. Guillemin, H. Begorre, E. Yvroud
� Autofluorescence spectroscopy of normal and pathological tissues of the bladder �, SPIE: Optical Biopsy, Vol. 3197, pp. 42-50,1997.
[9] O. A'Amar, F. Guillemin, H. Begorre, E. Yvroud
� Identification of endogenous fluorophores in normal and pathological tissues by the decomposition of autofluorescence spectra �, World Congress on Biomedical Physics and Biomedical Engineering: Session of Biophysical and Biochemical Measurements, Nice, France, 14-19 September 1997.
[10] O. A'Amar, D. Lignon, H. Begorre, F. Guillemin, E. Yvroud
� Gaussian Analyzing Model of Tissue Light-Induced Fluorescence for the Detection of Early Cancers �, SPIE: Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, Vol. 2979, PP. 574-584, 1997.
[11] J. Blais, J.-J. Padilla-Ybarra, G. Bourg-Heckly, O. A'Amar, J. Etienne, F. Guillemin
� UV-induced autofluorescence spectroscopy and diagnosis of early stage tumors �, 7th Congress of the European Society for Photobiology. Stresa, Italy, 1997.
[12] J.-J. Padilla-Ybarra, G. Bourg-Heckly, O. A'Amar, J. Blais, J. Etienne, F. Guillemin
� UV-induced autofluorescence spectroscopy in Barrett?s esophagus �, SPIE: Optical Biopsy, Vol. 3197, pp.54-59, 1997.
[13] E. Bossu, O. A'Amar, R.M. Parache, D. Notter, P. Labrude, C. Vigneron, F. Guillemin.
� Determination of the maximal tumor/normal skin ratio after HpD or m-THPC administration in hairless mouse (Skh-1) by fluorescence spectroscopy, a non invasive method �, Anti-Cancer Drugs, No. 8, pp. 67-72, 1997.
[14] H. Rezzoug, O. A'Amar, M. Barberi-Heyob, J-L. Merlin, L. Bezdetnaya, F. Guillemin
� In vivo pharmacokinetics and photodynamic activity of meta-tetra (m-hydroxyphenyl) chlorin (mTHPC) in human tumor bearing mice �, 7th congress of the European Society for Photobiology, Stresa, Italy, 8-13 September 1997.
[15] H. Rezzoug, O. A'Amar, M. Barberi-Heyob, D. Lignon, J-L. Merlin, F. Guillemin
� Biodistribution de la mTHPC sur mod�le tumoral murin �, 16�me Forum de canc�rologie, Paris, 17-19 Juin 1996, Bull Cancer, Vol. 83, No. 6, pp. 429, 1996.
[16] O. A'Amar, D. Lignon, H. Begorre, F. Guillemin, E. Yvroud
� Light induced fluorescence spectroscopy: a clinical instrumentation for tissue characterization �, The Annual IAR Conference, Karlsruhe, Germany, 21-22, November 1996.
[17] H. Rezzoug, M. Barberi-Heyob, O. A'Amar, J-L. Merlin, F. Guillemin
� Pharmacocin�tique intratumorale de la mTHPC : Optimisation du traitement Photodynamique �, 6�me Journ�e du G.P.C.O., Ajaccio, Corse, France, 3-4 Octobre 1996.
[18] H. Rezzoug, O. A'Amar, M. Barberi-Heyob, J-L. Merlin, F. Guillemin
� In vivo photodynamic therapy with meso-tetra (m-Hydroxyphenyl) chlorin (mTHPC): Optimization of photodynamic efficiency evaluation �, SPIE: Photochimiotherapy: PDT and other Modalities, Vol. 2924, pp. 181-186, 1996.
[19] O. A'Amar, D. Lignon, O. M�nard, H. Begorre, F. Guillemin, E. Yvroud
� Ex vivo and in vivo autofluorescence spectroscopic measurements in normal and malignant tissues of the upper and lower respiratory tract �, The European Respiratory Journal, ERS annual Congress, Stockholm, Sweden, Vol. 9, Supplement 23, , p.375s, 7-11 September 1996.
[20] F. Guillemin, O. A'Amar, H. Rezzoug, D. Lignon
� In vivo light induced fluorescence spectroscopy: kinetics of meso-tetra (m-Hydroxyphenyl) chlorin (mTHPC) in normal and tumor mice tissues �, The 6th Biennial Meeting of the International Photodynamic Association, Melbourne, Australia, p. 3, 10-14 March 1996.
[21] O. A'Amar, D. Lignon, O. M�nard, H. Begorre, F. Guillemin, E. Yvroud
� Autofluorescence spectroscopy of normal and malignant tissues: both in vivo and ex-vivo measurements in the upper aero-digestive tract and lung tissues �, SPIE: Advances in Laser and Light Spectroscopy to Diagnose Cancers and Other Diseases III: Optical Biopsy, Vol. 2679, pp. 42-50, 1996.
[22] O. A?AMAR
� Spectroscopie de fluorescence tissulaire induite par laser in vivo : Caract�risation des tissus pathologiques ; Cin�tiques de photosensibilisants �, Prix Jeune Chercheur au Xve congr�s de la Soci�t� Fran�aise des Lasers M�dicaux (SFLM), ARCS 1800, Bourgogne, France, p. 30, 15-19 Janvier 1996.
[23] F. Guillemin, O. A'Amar, H. Rezzoug et al.
� Optical instrumentation suitable for a real time dosimetry during Photodynamic therapy �, SPIE: Optical methods for Tumor Treatment and Detection, Vol. 2627, pp. 92-99, 1995.
[24] D. Lignon, O. A'Amar, K. Khemis, F. Guillemin et al.
� D�tection pr�coce des tumeurs canc�reuses par imagerie et spectres de la fluorescence endog�ne �, Premier Colloque National OPT-DIAG 95: Diagnostic et Imagerie Optiques en M�decine, Paris, France, p. 12, 18-19 Mai 1995.
[25] F. Jaffry, O. A'Amar, D. Lignon, F. Guillemin et al.
� Dosim�trie en th�rapie photodynamique, Param�tres optiques : Concentration du photosensibilisant, Coefficient global d?att�nuation lumineuse, Pression partielle d?oxyg�ne �, Premier Colloque National OPT-DIAG 95: Diagnostic et Imagerie Optiques en M�decine, Paris, France, p. 27, 18-19 Mai 1995.
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