Brain's immune system

1. CNS¿¡ ÀÖ´Â microglia ¡æ form an extensive defensive network there.

2. three kinds of glial cells :

         ¢Â astrocytes : star-shaped, largest cell body

                                sop up extra neurotransmitter molecules around neurons

                         ¡æ protecting nerve cells form receiving too much stimulation

         ¢Â oligodendrocytes : next largest glial cell, produce myelin sheath

         ¢Â microglia : ?

3. Santiago Ramony Cajal

       : microglia : developing brain¿¡¼­ amorphous body·Î appear

                  ¡æ differentiate into extensively branched or ramified

                  ¡æ populate every region of the brain and touch neurons and astrocytes

       : responded dramatically when the brain was injured severely (â»ó½Ã, branched formÀÌ ¼öÃàÇؼ­ immature conformation À¸·Î return )

4. last state's microglia resembled macrophages

    macrophage´Â hurt or infected tissue¿¡ ¹ÝÀÀÇØ, affected area ·Î À̵¿ÇØ °Å±â¼­ proliferation

   ¡æ highly phagotic ÇØÁü.

    rounding of mature microglia reflected a metamorphosis to a phagocytic state

5. various antibodies that recognize proteins occurring exclusively on cells of the immune system were able to find their targets on microglia

mono clonal antibodies able to latch on to class II major histocompatibility antigens often bound well to microglia

6. microglia : critical to proper development of the embryo. may secret growth factors important to the formation of the CNS