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The Original series follows the 5 year mission of the USS ENTERPRISE NCC1701 before it's cancellation.
One of the twelve Constitution class starships.  The ship was captained by James T Kirk.  Serving aboard were 430 highly trained crew.  Together, they were the stuff of legends who made the name Enterprise into the history books.
 

James Tiberius Kirk

Career
Commander of the original starship Enterprise from 2264-2269.  At age 34, he was the youngest captain in Starfleet.  His Starfleet serial number was SC 937-0176 CEC.
Kirk was an Ensign aboard the Republic during the Academy.  He became the only cadet to have beaten the "no-win" Kobayashi Maru scenario.Only cadet to have beaten the "no-win" Kobayashi Maru scenario.  His posting was as a lietenant aboard the Farragut.
In 2267, Kirk became the first captain to stand trial for murder of Benjamin Finney and was later proved innocent of wrong doing.  Commendations at that time include the Palm leaf of Axanar Peace Mission, the Grankite Order of Tactics (Class of Excellence), and the Preantares Ribbon of Commendation (Classes First and Second).  Award for valor included the Medal of Honor, the Silver Palm with Cluster, the Starfleet Citation for Conspicuous Gallantry, and the Kragite Order of Heroism.

Family
Born in Iowa in 2233. James Kirk lost his older brother, George Samuel Kirk and sister-in-law, Aurelan Kirk, on planet Deneva due to the invasion of the Denevan neural parasites in 2267. Kirk's nephew, Peter Kirk survived. He had a son with Carol Marcus, David, who was killed by Kruge in The Search of Spock.  Kirk's only other child died unborn when the child's mother, Miramanee, was killed in Classic episode "The Paradise Syndrome."  However, Kirk may have other, unknown children since he has had several affairs with women in the past.

Interests
He seems well versed in literature, sometimes quoting famous poetry, and he loves books, antiques, Earth history and sports.  A personal challenge, free-climbing the sheer El Capitan mountain face in Yosemite National Park on earth, nearly cost him his life.  He is excellent in hand to hand combat.

Others
his heroes include Abraham Lincoln and Garth of Izar. 

2233 Born in Iowa on Earth(conjecture, "The Deadly Years" [tos])
2250 Admitted to Starfleet Academy, serves aboard USS Republic (conjecture, "Court Martial"[tos])
2254 Graduated from Starfleet Academy, begins serving aboard USS Farragut (conjecture, "Obession" [tos])
2261 Had son, David, with Carol Marcus (Star Trek II: The Wrath of Khan)
2263 Assumes command of Enterprise (conjecture)
2269 Returns from five-year mission, promoted to Admiral (Star Trek: The Motion Picture)
2271 Reassigned as Enterprise captain (Star Trek: The Motion Picture)
2281 Retires from Starfleet (Star Trek Generations)
2284 Returns to Starfleet, leaving Antonia (Star Trek Generations)
2286 Convicted of violated Starfleet orders (Star Trek IV: The Vovage Home)
         Assigned to command Enterprise-A (Star Trek IV: The Vovage Home)
2293 Retires again, believed killed at launch of Enterprise-B (Star Trek Generations)
2371 Emerges from nexus, killed at Veridian III (Star Trek Generations)

 

Spock

First officer of the Enterprise and the ship's science officer, who starts out as Lt. Commander in the show's first season and is Captain Spock by the second Trek film, later becoming an ambassdor in TNG. He is played by Leonard Nimoy. Spock is half-Vulcan, half human, and was raised by his parents, Amanda Grayson and Sarek, on Vulcan. He had a pet sehlat name I'Chaya when he was a child. His service record, as quted from Classic episode "Court-Martial," reads: "Serial no.: S179 276 SP; rank: Commander; commendations: Vulcan Scientific Legion of Honor, Award of Valor, and twice decorated by Starfleet Command." He has adopted his Vulcan heritage but finds it often difficult to come to terms with his human half. He is reserved, claims he has no emotions, and is a vegetarian. In Classic episode, "The Cage," he was only a lieutenant when he served under Pike. Spock has an A-7 computer rating, meaning he has very strong computer capabilities. HE can memorize things in a instant, calculate odds while performing other, non-related tasks, and is a genius at maths, science and computer programming. He also appears interested in literature, and quotes often from literary works by humans. He plays the Vulcan lyre (and many other musical instruments, including the piano) with great skill. He had not spoken to his father for 18 years prior to "Journey to Babel," and was betrothed to a woman, when they were both seven years old, name T'Pring. T'Prng divorces Spock during their "wedding" when Spock was in the midst of Pon farr.

2230 Born on planet Vulcan (conjecture, "Journey to Babel" [tos])
2237 Betrothed to T'Pring ("Amok Time" [tos])
2249 Enters Starfleet Academy, alienating his father ("Journey to Babel" [tos])
2252 First serves aboard the Enterprise ("The Menagerie" [tos])
2253 Graduates from Starfleet Academy (conjecture)
2267 Experiences pon farr, but is rejected by T'Pring ("Amok Time" [tos])
2270 Retires from Starfleet (Star Trek: The Motion Picture)
2271 Returns to Starfleet (Star Trek: The Motion Picture)
2277 Promoted to captain, teaches at academy (Star Trek II: The Wrath of Khan)
2285 Dies, but is reborn at Genesis Planet (Star Trek II: The Wrath of Khan, Star Trek III: The Search for Spock)
2293 Served as special envoy to the Klingon goverment
2368 Working undercover on Romulus for Vulcan/Romulan reunification ("Unification, Parts I and II" [tng])
2369 Helped arranged the defection of Romulan vice-proconsul M'ret to the Federation