Megumi is the fox doctor lady of the Kamiya dojo crew (according to Sano). Originally from a prominent family of doctors Megumi found her way to Tokyo after their death in a war. She was to study under a doctor as his assistant but he was making opium for a gangster named Takeda Kanryu. After a fight, Kanryu killed the doctor and forced Megumi to take over the opium production.
Megumi managed to escape and runs into town. Sanosuke and Kenshin are gambling with some of Sanosuke's friends in a game of dice and they're losing horribly.
Megumi runs into their game and sees Kenshin's sword so she asks for protection. One of the Oniwa Banshu, Beshimi has been sent to capture megumi but is easily defeated by Kenshin and Sano.
Megumi comes back to the dojo but the Oniwa Banshu follow her and Kenshin and Sanosuke are forced to fight on her behalf. In the battle Yahiko is hit by a poison dart and Megumi manages to get the ingredients together to help Dr. Genzai make a treatment to nurse Yahiko back to health.
Sano puts 2 and 2 together and realizes that Megumi was making opium and screams at Megumi - one of his friends had been given bad opium as a medicine and died.
Takeda, along with the Oniwa Banshu persuade Megumi to return by threatening the dojo, but Sanosuke overhears the threat. Kenshin and crew go to save Megumi and to face off against the Oniwa Banshu.
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